PC Gear Lab

5 Best Ergonomic Mouse for Large Hands in 2021

It’s challenging to get a mouse if you have large hands. Especially if you are looking for a mouse with some very specific aspects like good ergonomics and other features that you intend to use.

Whether you are a gamer or an office user; whether you are looking for a gaming mouse or a productivity mouse, an good mouse can hep you you with long hauls of PC usage. Here we look at the best ergonomic mouse for large hands that can provide you comfort for the long sessions.

While they will be a good fit and feel comfortable in the hand, you will also get the benefit of good performance and high accuracy for whatever tasks you will be doing on your computer.

There are many types of ergonomic mouse. Some are simple while are others are riddled with power features. Here we look at some popular models.

List of Best Ergonomic Mouse for Large Hands in 2021

The following large mice all feature ergonomic features. Most of the mice listed below are productivity mice, however some are also great for gamers with large hands.

  1. Logitech MX Master 3 – Recommended Ergonomic Mouse for Large Hands
  2. Evoluent VMCR – Wired and vertical with DPI indicator
  3. Razer Lancehead – Gaming Mouse for Large Hands
  4. Logitech G502 – Customizable Gaming Mouse with Programmable Buttons
  5. Logitech G604 – High-performance wireless gaming mouse

1. Logitech MX Master 3 – Recommended Ergonomic Mouse for Large Hands

This advanced wireless mouse is suitable for productivity tasks as it comes with features that will let you quickly complete tasks.

The scroll wheel makes use of electromagnets to provide not only faster scrolling, but also more precision when scrolling.

Furthermore, there’s a scroll button above the thumb rest that can be easily reached by people with large hands. This can be used for horizontal scrolling in documents or browsers.

One useful feature of this device comes from its support for Logitech Flow. With it, users will be able to sue up to three computers seamlessly.

While you will be able to move your cursor between each device independently without having to manually connect each, Logitech Flow will let you copy files on one computer and paste them on another. This revolutionizes file transfer capabilities.

The mouse is rechargeable and has a long-lasting battery. A single charge can last for weeks. You also get a 4000DPI sensor that provides precise tracking on almost any surface.

Besides that, it also has a comfortable shape. This makes it the best ergonomic mouse for large hands.

2. Evoluent VMCR – Wired and vertical with DPI indicator

This wired mouse has a design that offers a natural position. Its vertical profile offers a firm grip but also keeps their forearms in a natural position that prevents arm twisting and movement in ways that can lead to RSIs.

Its size makes it the best ergonomic mouse for large hands. It has a larger size with lots of surface area to catch a good grip. Furthermore, the bottom part has an extended lip that protects a user’s small finger from friction against the desk or other surfaces when using the mouse.

It uses an optical sensor with adjustable DPI levels. This lets users customize the speed of the cursor to their needs depending on the software they are using. Furthermore, there’s a group of LED indicators on the mouse that display what DPI level you are using.

With a downloadable driver, users can do more, including customizing any of the 5 programmable buttons to perform whatever function they need upon being clicked. This feature can come in handy when you have a lot of work and need shortcuts.

3. Razer Lancehead – Gaming Mouse for Large Hands

Razer is famous for making high-performance mice and the Lancehead is no exception. It comes with a 16000DPI optical sensor with adjustable values for a more comfortable experience.

The high levels can be great for quick reactions in games and low levels will be essential when doing things like design and photoshop where you need very precise cursor control.

It has mechanical switches that are very durable and are rated to be good for about 50 million clicks. This means that even those who do lots of gaming will use this for a long time before signs of wear start becoming apparent.

The device has a large size that is curved in a way that offers good support for the user. This makes it the best ergonomic mouse for large hands, especially when the user is a gamer who spends a lot of time playing.

It is also ambidextrous meaning both left and right-handed users can get up to speed with it.

Customization options include the RGB lighting and 9 programmable buttons. The settings can be saved on the mouse’s onboard storage for use with different computers.

4. Logitech G502 – Customizable Gaming Mouse with Programmable Buttons

For users with large hands who are after a good performance and high customizability, this is the mouse to get.

You get 5 individual 3.6-gram weights that can be distributed inside the device. If you need it to feel heavier this will certainly help.

Being a wired device means you get high response rates. For activities such as gaming, this is quite handy.

To further its performance, the mouse’s optical sensor has a 12000DPI maximum sensitivity level. This can be changed if need be to match what the user is doing, whether its work or play. But it does offer a convenient wat to switch DPI levels.

On the mouse surface are 11 fully programmable buttons. These are kept easily in the reach of the user and can be set up to respond differently based on the applications you’re in. And, with the customizable LED lighting, users can configure the device’s lighting to match their desk setup.

The customizable weights and unique design make this a comfortable device to use. Ultimately, its features add up to make this the best ergonomic mouse for large hands.

5. Logitech G604 – High-performance wireless gaming mouse

Users who prefer wireless mice over wired ones will appreciate the performance of the Logitech G604.

This mouse uses Bluetooth for connectivity, but if you want to switch to more demanding tasks where very low latencies are required; say gaming; you can switch to its second wireless option. Lightspeed.

This option reduces latency significantly to single digits and enables the user to play more competitive games.

The device uses batteries and to make it more efficient, it draws very little power so that a single AA battery can last you up to 10 days when using Lightspeed mode and if you’re on Bluetooth, the time gets extended to almost 5 months.

There is a total of 15 programmable buttons on this device, six of which are nicely placed just above the thumb rest. These can be customized via the downloadable G-Hub software from Logitech.

Furthermore, you get a 16000DPI sensor with an adjustable DPI for ultra-fast performance in games.

Coupling performance with a large and comfortable design makes this the best ergonomic mouse for large hands.


How to Choose the Right Ergonomic Mouse if You Have Large Hands?

Having a mouse with good features is desirable. But, it’s even better when the mouse is built ergonomically to offer comfort and support.

When considering the features, remember to get a sizeable mouse so that you don’t end up with a device that’s too small for you.

You can do this if you intend to use the fingertip grip. However, if this is not your plan then it’s recommended to get a good-fit device from the start.

Mouse Sizing

best ergonomic mouse for large hands

To get a good fit, you can either eyeball the mouse and approximate its size against your hand. However, the best way would be to get actual measurements of your hand.

You can measure from the tip of the ring finger to your wrist. With this value, all you will need to do is get a mouse that is at least that long.

If you do this, you end up with a device that will fit large hands perfectly and offer good comfort in the process.

Also Read: Best Mouse with Onboard Memory

Ergonomic Mouse

You can choose to get an ergonomic mouse of any style, whether vertical or slightly tapered at an angle.

This will offer good support for your hand and enable you to get more done without feeling any significant pain or discomfort.

Furthermore, ergonomic mice are not very expensive which is all the more reason to consider investing in one for the long term.

Also Read: Best Ergonomic Mouse for Carpal Tunnel


Depending on what you’re doing you will want a mouse whose performance matches your needs. Some people may be getting a mouse specifically for gaming and others will need one for work. At the same time, some users want to do both.

Having a mouse that will be effective for both work and play is a good choice from the get-go because you won’t feel locked out in one aspect.

One of the ways manufacturers ensures this is by having a device with adjustable DPI levels. These can be set up as needed with high levels for quick movement in games and low levels for more precise and calculated movements when doing accuracy-intensive work like the design.

The other important factor in determining the performance is whether is mouse wired or wireless.

Also Read: Best Mouse for Fingertip Grip

Key Takeaway

Having a fitting mouse for users with a large mouse is essential. Investing in one will save you from discomfort or other issues down the road.

A small mouse will force you to use awkward grips with your mouse. But a large ergonomic mouse will be ideal.

Final Words

If you have large hands and are looking for a comfortable productivity or gaming experience on PC, then you need the right mouse to match the size of your hands.

Here we looked at the best ergonomic mouse for large hands. The emphasis here is on the ergonomic characteristic of the mouse. An ergonomic mouse helps in alleviating any discomfort or pain that may arise from prolonged use of a mouse.

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