5 Best Ergonomic Mouse for Large Hands in 2022

Last Updated on December 17, 2021

It’s challenging to get a mouse if you have large hands. Especially if you are looking for a mouse with some very specific aspects like good ergonomics and other features that you intend to use.

Whether you are a gamer or an office user; whether you are looking for a gaming mouse or a productivity mouse, a good mouse can hep you you with long hauls of PC usage.

Here we look at the best ergonomic mouse for large hands that can provide you comfort for the long sessions.

The key to getting a mouse for large hands, aside from a larger length of the mouse, is to find one with a good thumb rest. A large mouse is generally intended to be used with a palm grip and for palm grip, resting your thumb can make your experience a lot more comfortable.

Again, you may or may not like a mouse with thumb rest, but if you are an average productivity user, it is something that you can look into.

While they will be a good fit and feel comfortable in the hand, you will also get the benefit of good performance and high accuracy for whatever tasks you will be doing on your computer.

There are many types of ergonomic mouse. Some are simple while are others are riddled with power features. Here we look at some popular models.

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Comparison of Top Ergonomic Mice for Large Hands

Logitech MX
Master 3
14151 x
84.3 x
Buy at
Naga X
8543 x
74 x
Buy at
119 -
43.8 x
86 x
Buy at
13545 x
80 x
Buy at
Logitech G502
Proteus Hero
121 -
40 x
75 x
Buy at

1. Logitech MX Master 3 – Recommended Ergonomic Mouse for Large Hands

Logitech MX Master 3

A high performance large form factor productivity mouse.

If there is one mouse that is synonymous with productivity and premium office use case, it is the Logitech MX Master 3. Like its smaller counterpart, the MX Anywere 3, this mouse comes filled to the brim with features.

Essentially, this is a large wireless mouse with a comfortable thumb rest. It’s large form factor and a heavy weight promotes a good palm grip for your large hands.

What separates this mouse from the rest are its unique features including its ability to connect to three devices simultaneously, which can be switched using a button.

Furthermore, the Logitech Flow feature allows it to copy files from one computer to another so long as they are connected to the same network.

Moreover, this mouse can operate on almost any surface including glass thanks to its DarkField sensor.

The mouse comes with three programmable buttons as well as a button below the vertical scroll wheel that can act as a shift key. Pressing which can allow you to access four more commands.

The mouse offers a most welcome horizontal scroll wheel, which can come in handy in software like video editors where you have scroll through a long timeline.

All in all, for productivity and power users, this is one of the best ergonomic mouse for large hands. It weight at about 141 grams making this among the heaviest mice out there.

2. Razer Naga X – Large Mouse for MMO Gamers and Professional Designers

Razer Naga X

An MMO mouse that doubles as a professional mouse for designers and editors.

This is essentially a large MMO gaming mouse. The catchiest aspect of this mouse is the array of programmable buttons it offers. Including the 12 programmable buttons on the side, it has a total of 16 on board.

Now while the intended purpose for this mouse is MMO gaming where you can assign the buttons on the side to actions, commands and spells, it can also work very well for professional users.

For professional software like 3D design software, video editors, CAD software, photo editors, you can assign your most used commands and even macros to the buttons using the included Razer Synapse 3.0 software thus improving your efficiency.

Another important aspect to point out there is that despite being a large mouse, this is quite light weight at 85 grams. A lighter mouse is easier to pan across the mouse.

Also, being a gaming mouse, it has a whopping 16,000 DPI optical sensor. Meaning it can be very precise in scrolling. However, since it lacks the Darkfield sensor like the one in the Logitech MX Master 3 above, it would not be able to work on all surfaces.

In short, if you are looking for a large mouse with buttons on the side, then this is one of the best ergonomic mouse for large hands.

3. Corsair Nightsword – Large Ergonomic Gaming Mouse

Corsair Nightsword

A very large FPS gaming mouse with a comfortable thumb rest.

Here we have a one of the largest mice in terms of height. Hence if you are looking for a gaming mouse that promotes a palm grip, then this is something that you can look into.

The mouse’s huge thumb rest is another attraction. It is not something that is easily found particularly on gaming mice. The mouse offers adjustable weights and hence depending upon your preference, this mouse can weight anywhere between 119-144 grams.

While the mouse does not have side buttons like those found on the Razer Naga X, it comes with 10 programmable buttons located in strategic positions which can allow you to set important actions and even macros to them.

You can assign multiple profiles to this mouse which can be changed with a press of a button depending upon the game and the application you use.

All in all, if you are looking for a highly capable and a comfortable gaming mouse, then this is one of the best ergonomic mice for large hands.

4. Logitech G604 –Wireless Gaming / Productivity Mouse

Logitech G604

A large wireless gaming mouse with graceful looks.

Next up we have a highly recommended wireless gaming mouse which can double as a productivity mouse.

While most gaming mice out there have very vibrant, loud and flamboyant looks, this has a more graceful and elegant touch to it. In order to promote simplicity, it even ditches RGB.

Hence, while this is essentially a gaming wireless mouse, it can be used in your office and for professional use as well.

There are many key differences between this and an average productivity wireless mouse. For starters, it has very fast polling rate of 1 ms which is critical for gaming.

Secondly, it comes with a high performance optical HERO sensor with 25K DPI. Normal mice generally resort to having 1K-4K DPI.

Thirdly, it has a whopping 15 programmable buttons. An average wireless productivity mice can have 3-5 programmable buttons.

In addition to all that, the mouse also features a comfortable palm grip along with a thumb rest. Six programmable buttons can be found on the side.

At 135 grams, this is a heavy mouse, but for large and bulky hands, this one of the most recommended large wireless mouse out there.

5. Logitech G502 Proteus Hero – Popular Gaming Mouse with a Ton of Buttons

Logitech G502 Proteus Hero

A highly affordable gaming mouse with a plethora of buttons.

Finally, here we have a rather well priced and another very popular gaming mouse out there which is equally praised by productivity users.

Like the G604 above, this too uses the high performance HERO sensor with 25K DPI. The HERO sensor is at the moment, one of the most advanced optical tracking sensor out there and particularly great for shooters.

But other than that, it comes with a large ergonomic body with a small thumb rest and 11 customizable buttons.

The mouse comes with adjustable weights and depending upon the configuration you choose, the mouse can weight anywhere between 121-139 grams.

In short, if you want to make a bee line for one of the most popular gaming model, then this among the best ergonomic mouse for large hands.


What is Your Preferred Grip?

mouse grips

Before investing a large mouse, it is important to understand what you preferred grip style is there.

There are three grip styles for using your mouse i.e fingertip, claw and palm.

According to a survey by Joshua Goldman, the most preferred grip style for most users is the palm grip. This is the grip style where you essentially rest the entirety of your palm and your fingers on the mouse.

For this grip to work, you need to have a large mouse. With a smaller mouse, either its height will not be high enough to give a cushion to your hand, or your fingers will extend too far from the buttons.

Hence for a palm grip to work, you need to look at both the size of your hands a well as the size of the mouse.

How to Choose the Right Ergonomic Mouse if You Have Large Hands?

Having a mouse with good features is desirable. But, it’s even better when the mouse is built ergonomically to offer comfort and support.

When considering the features, remember to get a sizeable mouse so that you don’t end up with a device that’s too small for you.

You can settle for smaller mice if you intent for a fingertip grip. However, if this is not your plan then it’s recommended to get a good-fit device from the start.

Mouse Sizing

best ergonomic mouse for large hands
Source: Logitech MX Master 3

To get a good fit, you can either eyeball the mouse and approximate its size against your hand. However, the best way would be to get actual measurements of your hand.

You can measure from the tip of the ring finger to your wrist. With this value, all you will need to do is get a mouse that is at least that long.

If you do this, you end up with a device that will fit large hands perfectly and offer good comfort in the process, considering the palm grip, which requires the longest length.

Also Read: Best Mouse with Onboard Memory

Ergonomic Mouse and Thumb Rest

You can choose to get an ergonomic mouse of any style, whether vertical or slightly tapered at an angle.

This will offer good support for your hand and enable you to get more done without feeling any significant pain or discomfort.

Furthermore, ergonomic mice are not very expensive which is all the more reason to consider investing in one for the long term.

The most basic ergonomic functionality that you can find on any mouse with the thumb rest. Many large mice have a thumb rest.

However, most mice are only intended for right hand users. Left-hand users are generally forced to use the ambidextrous mice which lack a thumb rest.

Also Read: Best Ergonomic Mouse for Carpal Tunnel


Depending on what you’re doing you will want a mouse whose performance matches your needs. Some people may be getting a mouse specifically for gaming and others will need one for work. At the same time, some users want to do both.

Having a mouse that will be effective for both work and play is a good choice from the get-go because you won’t feel locked out in one aspect.

There are plenty of key factors to look into here i.e programmable keys, multiple PC control, wireless, overall DPI, whether it can work on glass surface or not, how good the mapping software is, the material used etc.

The following video explains if premium wireless gaming mice  are as good as wired counterparts.

Also Read: Best Mouse for Fingertip Grip

Weight Consideration

Getting a large mouse can be a double edged sword for some. While they can fit perfectly in medium to large hands and can promote a comfortable palm grip, owing to their overall size, they can also be quite heavy.

Take the Logitech Master MX 3, this mouse weight a whopping 141 grams. There are few mice like the Razer Naga X that are large have a lightweight construction, but these are quite rare to find.

Final Words

If you have large hands and are looking for a comfortable productivity or gaming experience on PC, then you need the right mouse to match the size of your hands.

Here we looked at the best ergonomic mouse for large hands. The emphasis here is on the ergonomic characteristic of the mouse. An ergonomic mouse helps in alleviating any discomfort or pain that may arise from prolonged use of a mouse.


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